Choline deficient diet induced hepatosteatosis reduces hepatic Natural Killer (NK) T‐cell numbers ‐ role of Interleukin‐12
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چکیده
منابع مشابه
Role of natural killer (NK) cells during pregnancy: A review
The homeostasis is maintained by the immune system which is constituted a network of organs, cells and molecules that act to combating the assaults affecting the body. The immune function has been conceptually divided into innate immunity and acquired immunity. Among the effector cells of innate immunity are the natural killer cells (NK), they play an important role in the reproductive immunolo...
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Article history: Received on: 02/06/2017 Accepted on: 15/07/2017 Available online: 30/09/2017 Objective: The present study aimed to evaluate the neuro-protective and hepato-protective activity of melatonin (MLN) on non-alcoholic steatohepatitis (NASH) in albino rats induced by methionine and choline deficient (MCD) diet. Material and Methods: To achieve this aim, rats were fed MCD diet for 8 we...
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Natural killer (NK) cells play a crucial role in regulating immune functions. Few studies have characterized canine NK cells. We previously demonstrated that canine peripheral blood lymphocytes (PBLs) with a low surface CD5 density (CD5lo) are considered a critical NK population. Natural killer cells in most mammals do not express T-cell markers, but canine CD5lo cells express surface molecules...
متن کاملMechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet.
The methionine choline-deficient (MCD) diet results in liver injury similar to human nonalcoholic steatohepatitis (NASH). The aims of this study were to define mechanisms of MCD-induced steatosis in insulin-resistant db/db and insulin-sensitive db/m mice. MCD-fed db/db mice developed more hepatic steatosis and retained more insulin resistance than MCD-fed db/m mice. Both subcutaneous and gonada...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a631-c